University of California, San Francisco
374 Parnassus Avenue
San Francisco, CA 94143-0500
Phone: 415-476-9026
Fax: 415-476-9370
Email: Lindsey.Criswell@UCSF.edu
Website: http://medicine.ucsf.edu/lupus
Dr. Criswell received her M.D. (1986) from the University of California, San Francisco and her M.P.H. (1992) from the University of California, Berkeley. She completed a postdoctoral fellowship in Rheumatology at the University of California, San Francisco. She joined the faculty of the UCSF Division of Rheumatology in 1992. Dr. Criswell also completed a D.Sc. degree in genetic epidemiology at the Netherlands Institute of Health Sciences. In recognition of her research and mentoring contributions, Dr. Criswell received the Henry Kunkel Young Investigator Award from the American College of Rheumatology in 2003 and the Kirkland Scholar Award for the period 2006 through 2008.
Research Interests:
The focus of my research program is the genetics and epidemiology of human autoimmune disease, particularly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). During the past several years, my research unit has devoted substantial effort to performance of genome wide association studies (GWAS) of SLE and RA. This work has led to the identification of over 20 genes each for RA and SLE and revealed underlying biologic pathways responsible for disease onset and progression. Given the heterogeneity of these disorders, we are also devoting substantial effort to the refinement of genotype-phenotype associations, such as the specificity of genetic associations for serologic or clinical subphenotypes. Several genes we are studying, including STAT4 and TNFAIP3, are also of interest due to emerging evidence supporting their association with multiple autoimmune disorders and phenotypes. Given the strong association of the major histocompatibility complex (MHC) region with multiple autoimmune disorders, we are currently performing fine mapping studies of this region in order to further define the complex genetic associations of this region with SLE, RA and related phenotypes. Lastly, we are pursuing studies in order to better understand ethnic differences in autoimmune disease risk and outcome. This work utilizes highly selected genetic markers (e.g., Ancestry Informative Markers, or AIMs) and principal component and other methods of statistical analysis that allow for detailed characterization of individuals and populations in terms of continental and intra-continental genetic ancestry.
Recent Publications:
Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD. A genome wide association study of systemic lupus erythematosus. Nature Genetics, 2008: 40(2): 204-10.
Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira R, Pant PVK, Ballinger DG, Kosoy R, Demirci FY, Kamboh I, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlquist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen A-C, Criswell LA, Gregersen PK, Behrens TW. Association of systemic lupus erythematosus with C8orf13/BLK and ITGAM/ITGAX. The New England Journal of Medicine, 2008: 358(9): 900-9.
Taylor KE, Remmers EF, Lee AT, Ortmann WA, Plenge RM, Tian C, Chung SA, Nititham J, Hom G, Kao AH, Demirci FY, Kamboh MI, Petri M, Manzi S, Kastner DL, Seldin MF, Gregersen PK, Behrens TW, Criswell LA. Specificity of the STAT4 genetic association for severe disease manifestations of SLE. PLoS Genetics, 2008; 4 (5): e1000084.
Musone SL, Taylor KE, Lu T, Nititham J, Ferreira RC, Ortmann W, Shiffrin N, Petri MA, Kamboh MI, Manzi S, Seldin MF, Gregersen PK, Behrens TW, Ma A, Kwok P-Y, Criswell LA. Multiple Polymorphisms in the TNFAIP3 Region are Independently Associated with Systemic Lupus Erythematosus. Nature Genetics, 2008: 40 (9): 1062-4.
Kaiser R, Barton JL, Chang MN, Catanese JJ, Li YN, Begovich A, Criswell LA. Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis. Genes and Immunity, 2009; 10 (5): 495-502.
Chung SA, Tian C, Taylor KE, Lee AT, Ortmann WA, Hom G, Graham R, Nititham J, Kelly JA, Morrisey J, Wu H, Yin H, Alarcón-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, Manzi S, Petri M, Gregersen PK, Langefeld CD, Behrens TW, Seldin MF, Criswell LA. Substructure in European-derived populations is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis and Rheumatism, 2009; 60 (8): 2448-56.
Gregersen PK, Amos CI, Lee AT, Lu E, Remmers EF, Kastner D, Seldin MF, Criswell LA, Plenge RM, Holers VM, Mikuls T , Sokka T, Bridges SL, Begovich A, Siminovitch K. C-Rel, a member of the NF-ĸB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nature Genetics, 2009; 41 (7): 820-3.
Gateva V, Sandling J, Hom G, Taylor KE, Chung SA, Sun X, Ortmann W, Kosoy R, Ferreira R, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson A, Rantapää-Dahlqvist S, Baechler EC, Brown EE, Alarcón GS, Edberg JC, Ramsey-Goldman R, McGwin, Jr.G, Reveille JD, Vilá LM, Kimberly RP, Manzi S, Petri MA, Lee A, Gregersen PK, Seldin MF, Rönnblom L, Criswell LA, Syvänen A-C, Behrens TW, Graham RR. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1, and IL10 as novel risk loci for systemic lupus erythematosus. Nature Genetics, 2009; 41 (11): 1228-33.
Barcellos LF, May SL, Ramsay PP, Quach H, Lane JA, Nititham J, Noble JA, Taylor KE, Quach D, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA. High density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genetics, 2009; 5 (10): e1000696.
Richman IB, Chung SA, Taylor KE, Kosoy R, Tian C, Ortmann WA, Nititham J, Lee AT, Rutman S, Petri M, Manzi S, Behrens TW, Gregersen PK, Seldin MF, Criswell LA. European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent. Genes and Immunity, 2009: Oct 22 [Epub ahead of print]
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