University of California, San Francisco
374 Parnassus Avenue, 1st Floor, Box 0500
San Francisco, CA. 94143-0500
phone: 415-514-1673
fax: 415-476-9370
Education:
Dr. Chung completed her MD (2001) at Johns Hopkins University where she was also an intern and resident (2001-04). She was a Rheumatology Clinical Fellow at UCSF (2004-07), and joined the UCSF faculty in 2007. Dr. Chung completed a Master’s Degree in Advanced Studies in Clinical Research at UCSF (2008).
Licensure:
Board certification, Rheumatology (2007)
Board certification, Internal Medicine (2004)
Medical License, State of California
Research Interests:
The central goal of my research program is to discover genetic and epigenetic factors that influence autoimmune disease susceptibility and its manifestations, in order to identify biologic pathways involved in disease pathogenesis and potential targets for therapeutic intervention. Current projects focused on systemic lupus erythematosus (SLE) include genome-wide association studies of lupus nephritis and autoantibody production, detailed investigations of the major histocompatilibity complex associations with SLE manifestations using high-density single nucleotide polymorphism (SNP) genotyping, and DNA methylation studies of anti-dsDNA autoantibody production in SLE. My clinical interest is systemic vasculitis, and I am developing projects studying the role of genetics and epigenetics in these diseases.
Selected publications:
Papers:
- Chung SA, Tian C, Taylor KE, Lee AT, Ortmann WA, Hom G, Graham RR, Nititham J, Kelly JA, Morrisey H, Wu H, Yin H, Alarcón-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, Manzi S, Petri M, Gregersen PK, Langefeld CD, Behrens TW, Seldin MF, and Criswell LA. European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis Rheum 2009; 60(8):2448-2456.
- Richman IB, Chung SA, Taylor KE, Tian C, Nititham J, Rutman S, Petri M, Manzi SM, Gregersen PK, Seldin MF, Criswell LA. European population substructure predicts disease phenotype among North Americans of European descent with systemic lupus erythematosus. Genes Immun (in press)
- Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, and Criswell LA. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet. 2009 Oct; 5(10):e1000696.
- Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, Ortmann W, Kosoy R, Ferreira RC, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Rantapää-Dahlqvist S, Baechler EC, Brown EE, Alarcón GS, Edberg JC, Ramsey-Goldman R, McGwin G Jr, Reveille JD, Vilá LM, Kimberly RP, Manzi S, Petri MA, Lee A, Gregersen PK, Seldin MF, Rönnblom L, Criswell LA, Syvänen AC, Behrens TW, and Graham RR. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet. 2009 Nov;41(11):1228-33.
- Taylor KE, Remmers EF, Lee AT, Wortmann WA, Plenge RM, Tian C, Chung SA, Nititham J, Hom G, Kao AH, Demirci FY, Kamboh MI, Petri M, Manzi S, Kastner DL, Seldin MF, Gregersen PK, Behrens TW, and Criswell LA. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet 2008; 4(5): e1000084.
- Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, and Behrens TW. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 2008; 358(9):900-9. Epub 2008 Jan 20.
Reviews:
- Chung SA, and Seo P. Microscopic polyangiitis. Rheum Dis Clin North Am. In press.
- Chung SA, and Seo P. Advances in the use of biologic agents for the treatment of systemic vasculitis. Curr Opin Rheumatol 2009; 21(1):3-9.
- Chung SA, and Criswell LA. PTPN22: its role in SLE and autoimmunity. Autoimmunity 2007; 40(8):582-90.
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